Silicones are known for their excellent biocompatibility and are widely used as active ingredients, antifoaming agents, and excipients for pharmaceutical applications. They are used to relieve the painful symptoms of gas in the stomach and intestines and also treat the symptoms of stomach acid, such as stomach upset, heartburn, and acid indigestion. Silicones as excipients support the design of pharmaceutical formulations and are crucial for drug delivery within the body; they deliver foam control and lubrication and facilitate the physiological absorption of the drug. In which, Simethicone USP and IP emulsions at different concentrations are incorporated in gastrointestinal medicaments and antacid products, and Dimethicone is used as an excipient in topical medicated preparations.